Perineuronal Net Receptor PTP? Regulates Retention of Memories

Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods intensive learning, usually late childhood, and they help long-term preservation newly acquired skills information. Modulation PNN function various techniques enhances plasticity regulates memories, which may be beneficial when memory persistence entails negative symptoms such as post-traumatic stress disorder (PTSD). In this study, we investigated PTP? [receptor-type tyrosine-protein phosphatase S, a that is activated binding chondroitin sulfate proteoglycans (CSPGs) from PNNs] memories using Novel Object Recognition Fear Conditioning models. We observed mice haploinsufficient for PTPRS gene (PTP? +/– ), although having improved short-term object recognition memory, display impaired both paradigm, compared to WT littermates. However, did not show any differences behavioral tests do heavily rely on flexibility, Elevated Plus Maze, Open Field, Marble Burying, Forced Swimming Test. Since has been shown interact with dephosphorylate TRKB, activation receptor its downstream pathways limbic areas known associated memory. found phosphorylation TRKB PLC? are increased hippocampus, prefrontal cortex, amygdaloid complex mice, but other TRKB-mediated signaling affected. Our data suggest downregulation promotes different brain areas, improves performance disrupts tested animal Inhibition or disruption PNN-PTP?-TRKB might potential target disorders where modulation can beneficial.